Adamantanecarboxylic acid derivative as 11-β-hydroxysteroid dehydrogenase inhibitors and their preparation, pharmaceutical compositions and used for treatment of various diseases
Vicker N., Su X., Pradaux F., Reed MJ., Potter BVL.
The invention provides compds. of formula I, as 11-β-hydroxysteroid dehydrogenase inhibitors (11-β-HSD), which are useful in the treatment of various diseases. Compds. of formula I wherein R1 is (un)substituted fused polycyclic groups, (un)substituted (un)branched alkyl, and (un)substituted cycloalkyl; Z is a carbonyl group or a isostere of a carbonyl group; R2 is (un)substituted arom. ring and (un)substituted heterocyclic ring are claimed in this invention. Example compd. II was prepd. by amidation of adamantane-1-carbonyl chloride with 2-thiophenemethanamine. All the invention compds. were evaluated for their 11-β-HSD inhibitory activity. From the assay, it was detd. that compd. II exhibited 20-60 % inhibition of 11-β-HSD1. [on SciFinder(R)]