Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Cortisol is synthesized by 11β-hydroxysteroid dehydrogenase type 1, inhibitors of which may treat disease associated with excessive cortisol levels. The crystal structures of 11β-hydroxysteroid dehydrogenase type 1 that have been released may aid drug discovery. The crystal structures have been analyzed in terms of the interactions between the protein and the ligands. Despite a variety of structurally different inhibitors the crystal structures of the proteins are quite similar. However, the differences are significant for drug discovery. The crystal structures can be of use in drug discovery, but care needs to be taken when selecting structures for use in virtual screening and ligand docking.

Original publication




Journal article


Future Med Chem

Publication Date





367 - 390


11-beta-Hydroxysteroid Dehydrogenase Type 1, Animals, Binding Sites, Crystallography, X-Ray, Drug Discovery, Enzyme Inhibitors, Glutamate Dehydrogenase (NADP+), Guinea Pigs, Humans, Hydrocortisone, Hydrogen Bonding, Ligands, Metabolic Syndrome, Mice, Models, Molecular, Protein Conformation, Rats