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Nicotinamide 8-Br-hypoxanthine dinucleotide (8-Br-NHD+) was cyclised at the N1 position by the ADP-ribosyl cyclase from Aplysia californica to give cyclic 8-Br-inosine diphosphoribose (8-Br-N1-cIDPR), a novel membrane-permeant agonist of Ca2+ release in human T cells.


Journal article


Chem Commun (Camb)

Publication Date



1944 - 1945


ADP-ribosyl Cyclase, Cell Membrane, Copper, Cyclic ADP-Ribose, Humans, Hypoxanthine, Jurkat Cells