Acylation of lycoctonine: Semi-synthesis of inuline, delsemine analogues and methyllycaconitine
Blagbrough IS., Coates PA., Hardick DJ., Lewis T., Rowan MG., Wonnacott S., Potter BVL.
Lycoctonine has been acylated to afford sequentially inuline, delsemine analogues and methyllycaconitine using isatoic anhydride followed by S-(-)-methylsuccinic anhydride. This protocol is a rapid, facile method for the regiospecific introduction of the anthranilate ester moiety found in potent nicotinic acetylcholine receptor antagonists. © 1994.