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The trkB and trkC genes are expressed during the formation of the vestibular and auditory system. To elucidate the function of trkB and trkC during this process, we have analysed mice carrying a germline mutation in the tyrosine kinase catalytic domain of these genes. Neuroanatomical analysis of homozygous mutant mice revealed neuronal deficiencies in the vestibular and cochlear ganglia. In trkB (-/-) animals vestibular neurons and a subset of cochlear neurons responsible for the innervation of outer hair cells were drastically reduced. The peripheral targets of the respective neurons showed severe innervation defects. A comparative analysis of ganglia from trkC (-/-) mutants revealed a moderate reduction of vestibular neurons and a specific loss of cochlear neurons innervating inner hair cells. No nerve fibres were detected in the sensory epithelium containing inner hair cells. A developmental study of trkB (-/-) and trkC (-/-) mice showed that some vestibular and cochlear fibres initially reached their peripheral targets but failed to maintain innervation and degenerated. TrkB and TrkC receptors are therefore required for the survival of specific neuronal populations and the maintenance of target innervation in the peripheral sensory system of the inner ear.


Journal article



Publication Date





3381 - 3391


Animals, Base Sequence, DNA Primers, Ear, Ganglia, Sensory, Genotype, Germ-Line Mutation, Hair Cells, Auditory, Outer, Mice, Mice, Mutant Strains, Microscopy, Electron, Molecular Sequence Data, Neurons, Afferent, Polymerase Chain Reaction, Receptor Protein-Tyrosine Kinases, Receptor, trkB, Receptor, trkC, Receptors, Nerve Growth Factor