Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The DOPAC/dopamine and HVA/dopamine ratios in extracted whole tissue were determined to obtain an index of dopaminergic activity in various rat brain regions 24 h following 10 days' treatment with haloperidol (0.5 and 2 mg/kg) or sulpiride (10 and 100 mg/kg). Both neuroleptics caused a reduction in the metabolite/amine ratio in nucl. accumbens but not frontal cortex or substantia nigra. Haloperidol, but not sulpiride significantly reduced the HVA/dopamine ratio in striatum. A region-specific action of neuroleptics on brain dopamine neurons is discussed.


Journal article


Eur J Pharmacol

Publication Date





401 - 404


3,4-Dihydroxyphenylacetic Acid, Animals, Brain, Dopamine, Haloperidol, Homovanillic Acid, Male, Rats, Rats, Inbred Strains, Sulpiride, Tissue Distribution