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Publications

Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.

Mills SJ. et al, (2016), Biochemistry, 55, 1384 - 1397

The "Other" Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo-Inositol Chemistry).

Thomas MP. et al, (2016), Angew Chem Int Ed Engl, 55, 1614 - 1650

Designer small molecules to target calcium signalling.

Swarbrick JM. et al, (2015), Biochem Soc Trans, 43, 417 - 425

Fibrinogen - a possible extracellular target for inositol phosphates.

Grint T. et al, (2012), Messenger (Los Angel), 1, 160 - 166

Multivalent benzene polyphosphate derivatives are non-Ca2+-mobilizing Ins(1,4,5)P3 receptor antagonists.

Mills SJ. et al, (2012), Messenger (Los Angel), 1, 167 - 181

A synthetic polyphosphoinositide headgroup surrogate in complex with SHIP2 provides a rationale for drug discovery.

Mills SJ. et al, (2012), ACS Chem Biol, 7, 822 - 828

Benzene polyphosphates as tools for cell signalling: inhibition of inositol 1,4,5-trisphosphate 5-phosphatase and interaction with the PH domain of protein kinase Balpha.

Mills SJ. et al, (2008), Chembiochem, 9, 1757 - 1766

Biphenyl 2,3',4,5',6-pentakisphosphate, a novel inositol polyphosphate surrogate, modulates Ca2+ responses in rat hepatocytes.

Vandeput F. et al, (2007), FASEB J, 21, 1481 - 1491

Novel inositol phospholipid headgroup surrogate crystallized in the pleckstrin homology domain of protein kinase Balpha.

Mills SJ. et al, (2007), ACS Chem Biol, 2, 242 - 246

3-hydroxybenzene 1,2,4-trisphosphate, a novel second messenger mimic and unusual substrate for type-I myo-inositol 1,4,5-trisphosphate 5-phosphatase: Synthesis and physicochemistry.

Mills SJ. et al, (2006), Chembiochem, 7, 1696 - 1706

Interaction of the catalytic domain of inositol 1,4,5-trisphosphate 3-kinase A with inositol phosphate analogues.

Poinas A. et al, (2005), Chembiochem, 6, 1449 - 1457

Amplification and propagation of pacemaker Ca2+ signals by cyclic ADP-ribose and the type 3 ryanodine receptor in T cells.

Kunerth S. et al, (2004), J Cell Sci, 117, 2141 - 2149

First derivatives of myo-inositol 1,4,6-trisphosphate modified at positions 2 and 3: structural analogues of D-myo-inositol 1,4,5-trisphosphate.

Horne G. et al, (2004), Carbohydr Res, 339, 51 - 65

A definitive synthesis of D-myo-inositol 1,4,5,6-tetrakisphosphate and its enantiomer D-myo-inositol 3,4,5,6-tetrakisphosphate from a novel butane-2,3-diacetal-protected inositol.

Mills SJ. et al, (2003), Chemistry, 9, 6207 - 6214

Synthesis of D- and L-myo-inositol 1,2,4,6-tetrakisphosphate, regioisomers of myo-inositol 1,3,4,5 tetrakisphosphate: activity against Ins(1,4,5)P3 binding proteins.

Mills SJ. et al, (2003), Org Biomol Chem, 1, 3546 - 3556

Synthesis of potent Ins(1,4,5)P3 5-phosphatase inhibitors by modification of myo-inositol 1,3,4,6-tetrakisphosphate.

Mills SJ. and Potter BVL., (2003), Bioorg Med Chem, 11, 4245 - 4253

Synthesis of D- and L-myo-inositol 2,4,5-trisphosphate and trisphosphorothioate: structural analogues of D-myo-inositol 1,4,5-trisphosphate.

Mills SJ. et al, (2002), Carbohydr Res, 337, 1795 - 1801

InsP(3)-induced Ca(2+) release in permeabilized invertebrate photoreceptors: a link between phototransduction and Ca(2+) stores.

Ukhanov K. et al, (2001), Cell Calcium, 29, 335 - 345

myo-inositol 1,4,6-trisphosphorothioate and myo-inositol 1,3, 6-trisphosphorothioate: partial agonists with very low intrinsic activity at the platelet myo-inositol 1,4,5-trisphosphate receptor.

Murphy CT. et al, (2000), Mol Pharmacol, 57, 595 - 601

Inositol polyphosphate-mediated iron transport in Pseudomonas aeruginosa.

Hirst PH. et al, (1999), J Appl Microbiol, 86, 537 - 543

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