Carole Bataille
Postdoctoral Research Assistant in Medicinal Chemistry
Key publications
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Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds.
Cruz-Migoni A. et al, (2019), Proc Natl Acad Sci U S A, 116, 2545 - 2550
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BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions.
Bery N. et al, (2018), Elife, 7
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A Biased Agonist at Immunometabolic Receptor GPR84 Causes Distinct Functional Effects in Macrophages.
Lucy D. et al, (2019), ACS Chem Biol, 14, 2055 - 2064
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Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo.
Partridge FA. et al, (2017), PLoS Negl Trop Dis, 11
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Thiazolidine derivatives as potent and selective inhibitors of the PIM kinase family.
Bataille CJR. et al, (2017), Bioorg Med Chem, 25, 2657 - 2665
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Hydrogen-bonding-mediated directed osmium dihydroxylation
Donohoe TJ. et al, (2011), Organic Reactions, 76, 1 - 48
Recent publications
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Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia.
Cogswell TJ. et al, (2024), RSC Med Chem
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HDAC inhibitor derivatives induce differentiation of leukemic cells through two distinct and separable mechanisms
Kumar P. et al, (2024)
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Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson's.
Brimblecombe KR. et al, (2023), Eur J Neurosci
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Kinetic insights into agonist-dependent signalling bias at the pro-inflammatory G-protein coupled receptor GPR84.
Luscombe VB. et al, (2023), Eur J Pharmacol, 956
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Phenotypic screening identifies a trisubstituted imidazo[1,2-a]pyridine series that induces differentiation in multiple AML cell lines.
Josa-Culleré L. et al, (2023), Eur J Med Chem, 258
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Screening the Medicines for Malaria Pandemic Response Box chemical library onCaenorhabditis elegansidentifies re-profiled candidate anthelmintic drug leads
Nick M. et al, (2022)
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A cell-based screening method using an intracellular antibody for discovering small molecules targeting the translocation protein LMO2.
Bery N. et al, (2021), Sci Adv, 7
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The BET inhibitor CPI203 promotes ex vivo expansion of cord blood long-term repopulating HSCs and megakaryocytes.
Hua P. et al, (2020), Blood, 136, 2410 - 2415