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Analysis of metabolites in biofluids using nuclear magnetic resonance often requires the suppression of obscuring signals arising from water and macromolecules. This paper analyses the limitations of the pulse sequence most commonly used to achieve such suppression (presat-CPMG) and proposes new pulse sequences that do not share those limitations. The utility of these improved pulse sequences is demonstrated in a metabolomic study of multiple sclerosis (MS) patients.

Original publication

DOI

10.1039/c9an01005j

Type

Journal article

Journal

Analyst

Publication Date

02/12/2019

Volume

144

Pages

7270 - 7277

Keywords

Blood Chemical Analysis, Humans, Macromolecular Substances, Magnetic Resonance Spectroscopy, Metabolome, Metabolomics, Multiple Sclerosis, Water