International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function.
Barnes NM., Ahern GP., Becamel C., Bockaert J., Camilleri M., Chaumont-Dubel S., Claeysen S., Cunningham KA., Fone KC., Gershon M., Di Giovanni G., Goodfellow NM., Halberstadt AL., Hartley RM., Hassaine G., Herrick-Davis K., Hovius R., Lacivita E., Lambe EK., Leopoldo M., Levy FO., Lummis SCR., Marin P., Maroteaux L., McCreary AC., Nelson DL., Neumaier JF., Newman-Tancredi A., Nury H., Roberts A., Roth BL., Roumier A., Sanger GJ., Teitler M., Sharp T., Villalón CM., Vogel H., Watts SW., Hoyer D.
5-HT receptors expressed throughout the human body are targets for established therapeutics and various drugs in development. Their diversity of structure and function reflects the important role 5-HT receptors play in physiologic and pathophysiological processes. The present review offers a framework for the official receptor nomenclature and a detailed understanding of each of the 14 5-HT receptor subtypes, their roles in the systems of the body, and, where appropriate, the (potential) utility of therapeutics targeting these receptors. SIGNIFICANCE STATEMENT: This review provides a comprehensive account of the classification and function of 5-hydroxytryptamine receptors, including how they are targeted for therapeutic benefit.