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Methylation of 2′-deoxyadenosine 5′-phosphorothioate gives two diastereoisomeric triesters whose configurations can be assigned by 31P n.m.r. spectroscopy by methylation of an asymmetric mixture of the diastereoisomers of 2′-deoxyadenosine 5′-O- methylphosphorothioate after configurational assignment; this can be used as a simple method for stereochemical analysis of 2′-deoxyadenosine 5′-[16O,18O]phosphorothioate.

Original publication




Journal article


Journal of the Chemical Society, Chemical Communications

Publication Date



851 - 853