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The specificity of carbohydrate-protein interactions can greatly outstrip that of many other ligand-binding systems; such is the enormous density of information that sugars can convey. In addition, macromolecules allow for the fine-tuning of active drug delivery through their great ability to undergo site-specific modification and their inherent physicochemical properties. Once combined, these two factors suggest that sugar-macromolecule conjugates, targeted using endogenous carbohydrate binding proteins, are a promising route to the 'magic bullet'.

Type

Journal article

Journal

Curr Opin Drug Discov Devel

Publication Date

03/2002

Volume

5

Pages

279 - 288

Keywords

Animals, Carbohydrates, Drug Carriers, Drug Delivery Systems, Humans, Macromolecular Substances, Peptides, Polysaccharides, Proteins