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New M(II) bis(thiosemicarbazonato) complexes (M = Ni(II), Cu(II) and Zn(II)) featuring allyl groups at the exocyclic nitrogens have been synthesised. The complexes were characterised in solution by spectroscopic methods and their solid state structures determined by single crystal X-ray diffraction using synchrotron radiation. The Zn(II) complex was found to be intrinsically fluorescent and soluble in biocompatible media. The uptake of this Zn(II) complex in HeLa, MCF-7 and IGROV cancer cells was monitored by fluorescence microscopies (epi- and confocal fluorescence imaging). The radiolabelling to (64)Cu(II) bis(thiosemicarbazonato) complex was performed cleanly by transmetallation from the corresponding Zn(II) species using (64)Cu(OAc)(2).

Original publication

DOI

10.1039/b705227h

Type

Journal article

Journal

Dalton Trans

Publication Date

21/11/2007

Pages

4988 - 4997

Keywords

Cell Line, Tumor, Copper, Crystallography, X-Ray, Humans, Magnetic Resonance Spectroscopy, Microscopy, Fluorescence, Molecular Probes, Zinc