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The synthesis of tetrazoles derived from D-mannofuranose and both enantiomers of rhamnofuranose provides the first examples of tetrazole analogues of carbohydrates in the furanose form. The D-furanotetrazoles are potential mannosidase inhibitors whereas the L-rhamnotetrazole may interfere with the biosynthesis of cell walls of mycobacteria and provide a strategy for the treatment of tuberculosis and leprosy. © 1995.

Original publication

DOI

10.1016/0040-4039(95)01518-3

Type

Journal article

Journal

Tetrahedron Letters

Publication Date

09/10/1995

Volume

36

Pages

7507 - 7510