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We report the synthesis and characterisation of new, highly fluorescent, zinc complexes of bis(thiosemicarbazone) ligands incorporating extended aromatic backbones which are cytotoxic at levels comparable to cisplatin; cellular fluorescence imaging studies suggest these cause cell death by disruption of mitochondria.

Original publication

DOI

10.1039/b802806k

Type

Journal article

Journal

Dalton Trans

Publication Date

28/04/2008

Pages

2107 - 2110

Keywords

Apoptosis, Carcinoma, Cell Line, Tumor, Crystallography, X-Ray, Drug Screening Assays, Antitumor, Humans, Lethal Dose 50, Microscopy, Confocal, Mitochondria, Models, Molecular, Molecular Structure, Organometallic Compounds, Spectrometry, Fluorescence, Thiosemicarbazones, Toxicity Tests, Zinc