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The synthesis of 1-O-[(3S,4R)-3-hydroxytetrahydrofuran-4-yl]-alpha-D-glucopyranosid e 3,4,3'-trisphosphate (7), a novel Ca2+ mobilising agonist at the Ins(1,4,5)P3 receptor, designed by excision of two motifs of adenophostin A is reported, defining a potential minimal structure for potent glucopyranoside-based agonists of Ins(1,4,5)P3 receptors.


Journal article


Bioorg Med Chem Lett

Publication Date





453 - 458


Adenosine, Animals, Calcium, Carbohydrate Conformation, Cells, Cultured, Furans, Glucosephosphates, Glycosides, Inositol 1,4,5-Trisphosphate, Liver, Molecular Mimicry, Rats