Preparation of arylsulfonylbenzazoles as inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 and type 2
Vicker N., Su X., Ganeshapillai D., Purohit A., Reed MJ., Potter BVL.
Title compds. [I; 1 of R1, R2 = R5SO2N(R4)L; R4 = H, hydrocarbyl; R5 = hydrocarbyl; L = optional linker group; R1R2 = atoms form a ring; X = S, O, NR6, C(R7)(R8); R6-R8 = H, hydrocarbyl], were prepd. Thus, title compd. (II) inhibited 11β-HSD1 with IC50 = 6.6 μM. [on SciFinder(R)]