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Oscillations in cytosolic free calcium concentrations ([Ca2+]i) can be elicited in REF52 fibroblasts by three different modes of stimulation. We have previously demonstrated that [Ca2+]i oscillations result when these cells are simultaneously depolarized and stimulated with a hormone linked to phosphoinositide breakdown. Further evidence is now presented that such oscillations are linked to fluctuations in the concentration of IP3 and the Ca2+ content of an IP3-sensitive Ca2+ store. [Ca2+]i oscillations can also be generated in REF52 cells either by direct stimulation of G-proteins with GTP gamma S or AlF4- or by destabilizing the membrane potential and opening voltage-dependent calcium channels. This report compares the different types of oscillations and their mechanisms.


Journal article


Cell Calcium

Publication Date





153 - 164


Aniline Compounds, Animals, Biological Transport, Active, Calcium, Calcium Channels, Cell Line, Cell Physiological Phenomena, Cytosol, Diglycerides, Feedback, Fibroblasts, Guanosine 5'-O-(3-Thiotriphosphate), Inositol 1,4,5-Trisphosphate, Inositol Phosphates, Membrane Potentials, Organothiophosphorus Compounds, Periodicity, Photolysis, Signal Transduction, Terpenes, Thapsigargin, Xanthenes