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A concise synthesis of L-chiro-inositol 2,3,5-trisphosphate, a novel receptor agonist and a potent inhibitor of the metabolic enzymes which act upon D-myo-Inositol 1,4,5-trisphosphate, is reported using methodology which accomplishes the required regio-protection of L-chiro-inositol for phosphorylation in one step.

Original publication




Journal article


Journal of the Chemical Society, Chemical Communications

Publication Date



1014 - 1016