Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The role of central noradrenergic neurons in kindled seizures was assessed by comparison of alpha 2- and beta-adrenoceptor binding in the cerebral cortex from kindled and control rats. To minimize handling, which may modify kindling-induced changes in binding, the kindling protocol involved stimulation of the amygdala every hour for a maximum of 26 h. Twenty-four hours after kindling, down-regulation of beta-adrenoceptors was found in both olfactory cortex and the remaining neocortex, whereas alpha 2 down-regulation was confined to the olfactory cortex. At 21 days after kindling, the only change found was a down-regulation of beta-adrenoceptors in the neocortex. The results support the view that functional changes in central noradrenergic transmission are associated with the reduction in seizure threshold induced by kindling.


Journal article


Exp Neurol

Publication Date





108 - 117


Adrenergic Fibers, Amygdala, Animals, Cerebral Cortex, Kindling, Neurologic, Male, Olfactory Bulb, Rats, Rats, Inbred Strains, Receptors, Adrenergic, alpha, Receptors, Adrenergic, beta