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The role of central noradrenergic neurons in kindled seizures was assessed by comparison of alpha 2- and beta-adrenoceptor binding in the cerebral cortex from kindled and control rats. To minimize handling, which may modify kindling-induced changes in binding, the kindling protocol involved stimulation of the amygdala every hour for a maximum of 26 h. Twenty-four hours after kindling, down-regulation of beta-adrenoceptors was found in both olfactory cortex and the remaining neocortex, whereas alpha 2 down-regulation was confined to the olfactory cortex. At 21 days after kindling, the only change found was a down-regulation of beta-adrenoceptors in the neocortex. The results support the view that functional changes in central noradrenergic transmission are associated with the reduction in seizure threshold induced by kindling.

Type

Journal article

Journal

Exp Neurol

Publication Date

10/1985

Volume

90

Pages

108 - 117

Keywords

Adrenergic Fibers, Amygdala, Animals, Cerebral Cortex, Kindling, Neurologic, Male, Olfactory Bulb, Rats, Rats, Inbred Strains, Receptors, Adrenergic, alpha, Receptors, Adrenergic, beta