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In order to test the hypotheses that stimulation of non-N-methyl-D-aspartate (NMDA) receptors in the neostriatum causes the release of gamma-aminobutyric acid (GABA) from nigrostriatal neurones, dual microdialysis was carried out in the neostriatum and substantia nigra of freely moving rats. Application of kainic acid to the neostriatum caused a dose-dependent release of GABA both locally and, at the same time, from the ipsilateral substantia nigra. These effects were blocked by the non-NMDA receptor antagonist 6,7-dinitroquinoxaline-2,3-dione (DNQX). Direct application of kainic acid to the substantia nigra caused a DNQX-sensitive local release of GABA. It is concluded that excitatory amino acid receptor stimulation of the neostriatum releases GABA from striatonigral neurones and that stimulation of the substantia nigra causes the release from striatonigral terminals and/or the collaterals of nigrofugal neurones.

Type

Journal article

Journal

Neuroreport

Publication Date

02/06/1994

Volume

5

Pages

1233 - 1236

Keywords

Animals, Dose-Response Relationship, Drug, Injections, Kainic Acid, Male, Microdialysis, Neostriatum, Quinoxalines, Rats, Rats, Sprague-Dawley, Substantia Nigra, gamma-Aminobutyric Acid