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Several recent reports, including one in this journal, have reignited the debate about whether the calcium-mobilizing messenger, nicotinic adenine nucleotide diphosphate (NAADP) plays a central role in the regulation of calcium signalling in pancreatic β-cell. These studies have highlighted a role for NAADP-induced Ca(2+) mobilization not only in mediating the effects of the incretin, GLP-1 and the autocrine proliferative effects of insulin, but also possibly a fundamental role in glucose-mediated insulin secretion in the pancreatic β-cell.

Type

Journal article

Journal

Islets

Publication Date

09/2010

Volume

2

Pages

323 - 330

Keywords

Animals, Calcium, Calcium Channels, Calcium Signaling, Humans, Insulin-Secreting Cells, NADP