Career Development Fellow
Research at the interface of chemistry, biology and drug discovery.
As part of the Medicinal Chemistry Group in the Department of Pharmacology, our research involves the synthesis and development of biologically active small-molecules. This includes identification of new inhibitors by screening approaches, design of improved molecules using rational and computational guidance, and testing of molecules in biochemical, cellular and in vivo settings. Current Medicinal Chemistry projects include: development of molecules to reverse antibiotic resistance; development of inhibitors of the Hedgehog signalling pathway in cancer; identification of modulators of protease activity in cancer and development.
Our research in Chemical Biology involves the use of chemical methodology and small molecules to probe biological questions. This encompasses a range of methodology including organic synthesis, biorthogonal 'click' chemistry, and biochemical or mass spectrometry-based proteomic analyses. Current areas of interest include: generation of novel platforms for modulation of protein-protein interactions; profiling of small-molecule targets in vivo.
Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity
Panyain N. et al, (2020), J Am Chem Soc, 142, 12020 - 12026
Acylation-coupled lipophilic induction of polarisation (Acyl-cLIP): a universal assay for lipid transferase and hydrolase enzymes.
Lanyon-Hogg T. et al, (2019), Chem Sci, 10, 8995 - 9000
Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics
Storck EM. et al, (2019), Nat Chem, 11, 552 - 561
Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus
Lim CSQ. et al, (2019), Bioorg Med Chem, 27
Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane
Clulow JA. et al, (2017), Chem Commun (Camb), 53, 5182 - 5185