Lanyon-Hogg Group | Medicinal Chemistry & Chemical Biology
Our group uses synthetic chemistry and biochemistry to develop small-molecule therapeutics and generate new insights into fundamental biology. We are interested in using tool molecules and interdisciplinary methodology to identify and validate new drug targets.
As part of the Medicinal Chemistry Group in the Department of Pharmacology, our research involves the synthesis and development of biologically active small-molecules. This includes identification of new inhibitors by screening approaches, design of improved molecules using rational and computational guidance, and testing of molecules in biochemical, cellular and in vivo settings. Current Medicinal Chemistry projects include: development of molecules to reverse antibiotic resistance; development of inhibitors of the Hedgehog signalling pathway in cancer; identification of modulators of protease activity in cancer and development.
Our research in Chemical Biology involves the use of chemical methodology and small molecules to probe biological questions. This encompasses a range of methodology including organic synthesis, biorthogonal 'click' chemistry, and biochemical or mass spectrometry-based proteomic analyses. Current areas of interest include: generation of novel platforms for modulation of protein-protein interactions; profiling of small-molecule targets in vivo.
JOINING THE LAB
We are always on the lookout for intelligent and motivated people to join the lab. If interested, please make contact to discuss further (email@example.com). At the postdoctoral level, we are willing to support applications to fellowship programmes. At the PhD student level, recruitment is conducted via one of the Oxford University programmes; please note that these programmes normally close in January each year.
Anti-CD20 Disrupts Meningeal B-Cell Aggregates in a Model of Secondary Progressive Multiple Sclerosis.
Roodselaar J. et al, (2021), Neurol Neuroimmunol Neuroinflamm, 8
Non-neuronal cells in amyotrophic lateral sclerosis - from pathogenesis to biomarkers.
Vahsen BF. et al, (2021), Nat Rev Neurol
MULTIPLE SUBSTRATE RECOGNITION BY YEAST DIADENOSINE AND DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE THROUGH PHOSPHATE CLAMPING
POTTER B. et al, (2021), Science Advances
Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C.
Roney JC. et al, (2021), Dev Cell